Tag Archives: science

The Ties that Bind Us

There are any number of relationships, which transcend species lines, that are nonetheless vital for the proper functioning of the individual organisms within that biological relational field. These groups of organisms, or sometimes specific processes within these organisms, can form obligate (necessary) bonds that have the same characteristics as the relationships between the collection of vital organs in a singular body.
 
The relationships that define the integrity and continuing function of any single organism extends far beyond that singular organism’s membrane. Each organism exists by way of an extended network of mutually nourishing and defensive relationships that collectively nourish and defend the integrity of that community. This relational lens is far more useful to see the foundational principles of biology than is a reductionist, organism-centric lens.
 
The same community principle is what defines the strength and integrity of any complex adaptive system from a single cell, to organ, to the larger relationship economy we see expressed through ecosystems is also true of interpersonal relationships, families, groups, society and civilization itself. This is the underlying message communicated through the processes that define the biological economy – that forging mutualistic nourishing bonds, and by extension, a common defense, defines the level of adaptation any complex adaptive system will have to negotiate the environment.
 
Here is an example of one such inter-species relational bond that illustrates the type of bond that nourishes and protects a body of life, the same way organs in a multicellular creature relate to each other:
 
𝗡𝗲𝘄 𝗿𝗲𝗰𝗲𝗽𝘁𝗼𝗿 𝗶𝗻𝘃𝗼𝗹𝘃𝗲𝗱 𝗶𝗻 𝘀𝘆𝗺𝗯𝗶𝗼𝘀𝗶𝘀 𝗯𝗲𝘁𝘄𝗲𝗲𝗻 𝗹𝗲𝗴𝘂𝗺𝗲𝘀 𝗮𝗻𝗱 𝗻𝗶𝘁𝗿𝗼𝗴𝗲𝗻-𝗳𝗶𝘅𝗶𝗻𝗴 𝗿𝗵𝗶𝘇𝗼𝗯𝗶𝗮 𝗶𝗱𝗲𝗻𝘁𝗶𝗳𝗶𝗲𝗱
 
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Balance is the Key to Sustainable Systems

 

Balance is the key to sustainable systems. Even vital substances like water can become harmful when they are out of balance. Too much, or too little water, T too high or too low a temperature and so on is harmful. The correct range is key, and this range is determined by the environmental context. When it comes to complex biological systems like ourselves, many forms of balance come into play. How many and which type of cells, proteins and so on are part of the biological economy that has different players with different attributes, but all operate under the unified purpose of nourishing and defending the integrity of the whole system. This principle is echoed on many scales, for instance; we must seek our nourishment, but we must also defend against antagonists as a social community, as a species, and we must nourish and defend the planet if we are to continue. The point is, this nourish and defend in the context of the community principle is what defines a stable and sustainable system. But even these “nourish and defend” traits also must be in balance; proportional to the context of the environment, otherwise they too become harmful.

The same way we go into a highly reactive mode when stressed or faced with a perceived mortal threat – this fight or flight mode, where we try out behaviors that we would never consider in any other context goes into effect. It’s part of the innate systems embedded in our biological systems that go into effect as a means of defending against the loss of the integrity we depend on to remain coherent.

Our individual cells are equipped with these same defensive mechanisms on a smaller scale. When our cells are faced with stressors or mortal threats they also try out radical strategies in an attempt to hold on to integrity as well. These radical adaptive expressions that attempt to stem the tide of destruction can sometimes result in cancer, which produces a radical class of “survivalist” cells, highly focused on, and able to rapidly, adapt. Once they gain a foothold of fiercely adaptive cells in the context of our body, which requires a certain cooperative mutually nourishing relationship climate in order to function, it threatens the integrity we depend on at that larger biological community scale.

In other words, the cancer begins to exercise this highly adaptive “try any and everything adaptive strategy” as the cancerous cells begin to multiply. The cells begin operating as an adaptive agent in its own right, with dynamic adaptive aims that separate from the unified purpose of the body which spawned the cells. It is like a speciation within a single body. Rogue maundering raider cells pillaging the body to continue to exist, not recognizing that this tax will destroy the foundation on which they depend.

Because the hyper active highly adaptive capacity operates without regard to the integrity of the larger system in which the cells reside is why cancer cells, once they develop a communal relationship with one another, are so destructive, and why they are so difficult to eradicate once gain enough ground. Their capacity to adapt by developing radical strategies on the fly makes them a particularly foe to eradicate. In this case, lung cancer develops a digestive system.

Scientists Discover a Tiny Stomach Hidden Inside Lung Tumours, Because Cancer Is Changing

Cancer cells will do whatever it takes to survive.

https://www.sciencealert.com/scientists-discover-a-tiny-stomach-hidden-inside-lung-tumours-because-cancer-is-changing

How to Control Traffic on Cellular Highways

glutamate-transportation-neurosciencenewsInside cells, protein “motors” act like trucks on tiny cellular highways to deliver life-sustaining cargoes.

Now a team led by Rutgers University-New Brunswick researchers has discovered how cells deploy enzymes to place traffic control and “roadway under construction” signs along cellular highways.

“To stay alive and function, every cell in our body needs to transport cargoes to the place they’re needed inside the cell, in the right amount and at the right time,” said Robert O’Hagan, lead author of a new study and assistant research professor in the Human Genetics Institute of New Jersey and the Department of Genetics at Rutgers University-New Brunswick. “So there has to be a lot of organization in how transport inside the cell is regulated, and now we know a lot more about how that happens.”

via How to Control Traffic on Cellular Highways – Neuroscience News

In-Groups and Out-Groups: A Biological Perspective

There is a certain fungus that is able to control certain ants to serve as a vehicle to further its own reproductive ends. The ant, in this case, dies in service of reproducing the fungus. There is also the case of the bacterial parasite T. Gondii which edits rodent brains to be attracted to felines so they get eaten, which helps the bacteria to enter its spawning grounds, which is in a feline gut. (it also edits other mammal brains in different ways) There are numerous cases of parasites and viruses that have the capacity to influence other organisms in service of their specific ends. It could be said that this is the norm in nature – competing influences that ultimately result in emergent behaviors that we typically identify as belonging to “an organism” but are in fact based on the collective property of many organisms.

When we consider that we are also a collection of various organisms that are influenced by each other, each with various agendas and various means of carrying that agenda out, we can begin to see that what we call our choices, and what we think of as our identity, may in fact be a byproduct of the parliamentary constellation of influences that rises from the pool of biological organisms that define us. We may be a reflection of the relationship field from which we are composed which extends beyond human genetics.

A recognition of this, at least from the parasitic sense, there is a now “theory” on the block called ; “The parasite-stress theory” which sees our personal and cultural identities through the lens of the parasitic creatures that influence us to service their various needs. In some real respects, it posits that our cultures in large part are an emergent property of the parasitic microbes that influence our behaviors.

The evidence for this idea is the strong correlation between the strength of parasites in the relationship field of the people in a given culture and their relative state of peace or conflict in addition to whether or not the culture is conformist or individualistic etc. In other words, what we see as culture may be a mirror effect of the relationship field between organisms.

According to this video; the parasite-stress theory may be a general theory of culture and sociality. In a nutshell it acknowledges the fact that the various strategies organisms have to influence other organisms to serve its purposes do have a role in defining this thing we call us. My thought is that it would be a more accurate lens if it looked at the full spectrum of organisms, some of which are on the mutually beneficial range of influence – commensal organisms having a stake in the success of the community it depends on – and doing what they can to offer benefits such as stability, defense, long life and so on. In other words, I think this theory is on to something, but is not yet complete. If we factored in the full spectrum of influences, (rather than just the parasitic segment) we would be able to understand that our opportunity for cultivating an intentional experience of life, rather than riding ignorantly on the winds of biological chance, is rooted in whether or not we intentionally tend the biological relationship field of which we are, on which we depend and that defines this thing we call “us” to be inclined toward the commensal, mutually beneficial segment of the spectrum of relationships.

Biology Reveals Insights into Human Culture

This is an excellent documentary that illustrates how biological ecosystems find an equilibrium that is a suitable adaptive response to the environment. This means all the organisms that express nourishing and defense behaviors in a given ecosystem become specifically suited to the environment and each other. Islands are one of the places this biological balance is illustrated clearly; where the particulars of the environment along with the baseline biological ecosystem that inherited the island come to express a behavioral economy that is adaptive in that specific context. Islands with no large land predators may bring about flightless birds for instance because of the lack of need to fly away.

Christmas Island is an excellent illustration of how that biological equilibrium can be dramatically disrupted by a newcomer to the biological social economy. This disruption can expose weaknesses that are present because there was no need to build defenses against the strategies of the imported invader prior to its arrival. This is what drives biology’s own evolutionary expression of a “Game of Thrones” and may also be a good insight into the way the various human cultures evolved throughout the world – a reflection of populations finding equilibrium with the environment, reflecting its nature, coupled with the periodic need to adapt to “invaders” as we began to cross pollinate as a result of things like trade, climate shifts and so on, leading to the human version of “Game of Thrones”.

How Smell Shapes Our Lives

There is no thing that we do on a macro scale that is not echoed on many other scales, including micro. Like ripples in a pond the relationships that define biological systems and subsystem are characterized by recurring echoes of self similarity and a blend of dissonance. This blend of tradition and flexibility – of dedication to ritual and diversity – is what composes the adaptive range of behaviors we must express in proportion to the opportunities and challenges presented by way of a variable environment – and this is also what characterizes this magnificent symphony of structure we call biology. The capacity to use smell as a means of communicating and understanding that environment as well as negotiating it effectively is no exception to this rule. Here’s a closer look:

Cultivation Vs Domination

Science is increasingly recognizing that nature presents the most effective strategy as cultivation rather than domination – that the target is to cultivate a relationship field that attends to nourishing and protecting a community bound together with mutually beneficial ties as well as a willingness to defend the fruits that come from that community activity. We would do well to begin to apply this same cultivation vs domination principle to all aspects of life, from farming to interpersonal relationships to business and government, since our common ground is Earth.

From the article: “We have long believed that “good” immune cells recognise and defend against “bad” invaders. That’s why a large proportion of medicine has been directed at killing microbial enemies and conquering microbial infections.

This militaristic understanding of immunity reflected the culture of the 20th century, which was dominated by nation building and world wars between “us” and “them.” …a radical shift in understanding the relationship between humans and microorganisms occurred with the discovery that only 50% of the cells in our bodies are human. The rest are microbes, such as bacteria, yeasts (members of the fungus family), viruses, and even insects. Together, these make up the microbiome… Because we have evolved with microorganisms inside us, we now have specialised communities in our guts, on our skin, and in our mouths. Our microbes are understood to be so critical to our existence”

For more information: https://theconversation.com/essays-on-health-microbes-arent-the-enemy-theyre-a-big-part-of-who-we-are-79116

The Relationship Economy that Defines a Coherent Body of Life

The article link below describes how a single species of gut bacteria can reverse autism-related social behavior in mice.

The fact that a single organism can have so much influence on mouse behavior and experience is also a glimpse not only into the powerful biological drivers that result in what all organisms experience as life, but indeed what life experience is founded on. Our behaviors and experience, including whether and how much we are social, as well as whether or not we remain a coherent part of the biological economy over time and so on are based on the relational climate that forms as a result of a parliament of organisms and environmental conditions which together operate as a coherent body which influence behaviors and experience on multiple scales.

The notion that we are an individual species, defined by our local genetics and completely separate entities from other species is dissolving as a useful means to clearly define biology. A lens that sees biology as a relational economy that transcends our notions of individual species – one that renders the image that a coherent biological body consisting of organisms of many different genetic makeups networked together in diverse ways, forming a meta body, complete with a coherent integrated metabolism and the defense mechanisms to defend that integrity in the face of antagonists – is a more appropriate lens.

https://www.sciencedaily.com/releases/2016/06/160616140723.htm

Phylosymbiosis: Cooperative Relationships as a Matter of Survival

 

It has become increasingly apparent that larger organisms like ourselves cannot live alone. A certain community of bacterial associates must live in, and on a host organism. This relationship is sometimes essential for the host’s well being as well as that of the the microorganisms. Different animals have a specific array of microorganisms that function in roles that offer adaptive advantage in the context of the environment. These roles include digestion, protection from destructive pathogens and so on. They have also been shown to play roles in reproduction and sociality among other things.

This relationship between host and microbial organisms should perhaps come as no surprise because complex organisms such as ourselves arose from cooperative ties between microorganisms and viral components. We are, from a certain perspective, a microbial community ourselves as we are composed of a community of like cells, differentiated slightly into various organ roles that operate as a community. This same principle applies to the more fluid, extended microbial community in the environment.

How this community of relationships forms and develops between a host and the microbiome has been the focus of recent studies on the cutting edge of evolutionary biology. It appears that the relationship between host an microbiome can and does shape the evolutionary path of this collective “community”. Each organism plays a role as a voice in a choir, and the persistent demands of the environment is the choirmaster. The fact that there are severe fitness disadvantages in hosts that don’t have an appropriate blend of microorganism companions is an indication of how crucial this cooperative communal role is to develop. Together, the host and all the corresponding microorganisms that live in together are called a metaorganism.

The host organism actively cultivates a climate to identify microbial friends from enemies. One of the things that emerged in terms of understanding how these communal relationships are forged is that the host’s is able to recognize phylogenic similarities between itself and the various microbial genomes. It does so using its immune system as the sensor to differentiate friend from foe. In other words; the host’s genotype is in part responsible for the composition of microbiota which the metaorganism consists of. The more distantly related species, the less preferred it is. Of particular note is the fact that self similarity in the collective genomes between host and microbe are tied to their inclination to service each other’s needs. Phylogenetic similarity is what appears to incline them to confer advantage toward each other. In other words, the more similar, the more likely their behaviors will center on cooperation.

The host’s immune system is the vehicle that cultivates specific relationships from the environmental microbiome. It is this recapitulation of host phylogeny by microbiota that is called phylosymbiotic relationship. Over time, this relationship field in the metaorganism inclines toward a host-bacterial homeostasis that collectively offers adaptive advantages and in some cases, obligate (necessary) relationships, without which the communal social system would break down.

For more on this, see Seth Bordenstein’s talk on the topic.

On Bacterial Intelligence And Sociality

Although Eshel-Ben Jacob Died in June of 2015, during his life he was a leader in the theory of self-organization and pattern formation in open systems. He extended this work to include adaptive complex systems and biocomplexity. He studed bacterial self-organization, through a lens that holds bacteria the key or seminal force that can lead to our understanding how larger biological systems work, incluging ourselves.

Microbes are often thought of as reactive participants in the scheme of life. Mindlessly chewing away on food they happen to stumble on without much in the way of insight about the future, how they fit in to the larger biological community, or any other kind of depth perception necessary to navigate with competency toward a more certain future in a sometimes antagonistic and ever changing world, but this is simply not so according discoveries made by Eshel-Ben Jacob. He discovered, among other things that they exhibit population control, have an understanding of the need for biological diversity in order to deal effectively with changing environments, in addition to a powerful range of adaptive tools to negotiate the environment. As it turns out, bacteria may not be simple in any respect, they may merely express their intelligence and social life in different ways, on different scales than we do. This thought provoking lecture, given at google, is well worth a listen.